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Immuno-Service

Demonstrating Immuneed’s unique whole blood loop assay.

Extracorporeal human whole blood assay, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics. Fletcher E.A.K. et al. International Immunopharmacol, 2017

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The use of whole blood loop assay to investigate biodistribution of human adenovirus.

Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer. Yu D. et al. Neuroendocrinology, 2017

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The use of human whole blood loop assay to investigate effector mechanisms of a therapeutic antibody.

Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells. Vogel S. et al. Scientific Reports, 2015

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The use of the human whole blood loop assay to investigate nucleic acid based immunotherapeutic interactions with complement.

Complement activation by CpG in a human whole blood loop system: mechanisms and immuno-modulatory effects. Mangsbo S.M. et al. Immunology, 2009

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The use of whole blood loop assay to study T cell recall responses.

Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System. Fletcher E.A.K. et al Journal of Immunology, 2018

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Immuno-Oncology

A novel targeting and adjuvant strategy to improve T cell responses.

Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses. Mangsbo S.M. et al. Molecular Immunology, 2017

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How circulating antibodies facilitates cross-priming of antigens.

Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo. van Montfoort N. et al. European Journal of Immunology, 2012

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Using antibodies as shield to protect vaccine components can enhance the effect of the vaccine.

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity. van Montfoort N. et al PNAS, 2009

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The use of the human whole blood loop assay to investigate nucleic acid based immunotherapeutic interactions with complement.

Complement activation by CpG in a human whole blood loop system: mechanisms and immuno-modulatory effects. Mangsbo S.M. et al. Immunology, 2009

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