Demonstrating Immuneed’s unique whole blood loop assay.
Extracorporeal human whole blood assay, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics. Fletcher E.A.K. et al. International Immunopharmacol, 2017
The use of whole blood loop assay to investigate biodistribution of human adenovirus.
Preclinical Evaluation of AdVince, an Oncolytic Adenovirus Adapted for Treatment of Liver Metastases from Neuroendocrine Cancer. Yu D. et al. Neuroendocrinology, 2017
The use of human whole blood loop assay to investigate effector mechanisms of a therapeutic antibody.
Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells. Vogel S. et al. Scientific Reports, 2015
The use of the human whole blood loop assay to investigate nucleic acid based immunotherapeutic interactions with complement.
Complement activation by CpG in a human whole blood loop system: mechanisms and immuno-modulatory effects. Mangsbo S.M. et al. Immunology, 2009
The use of whole blood loop assay to study T cell recall responses.
Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System. Fletcher E.A.K. et al Journal of Immunology, 2018