Monocytes have a fundamental role in the immune response, especially in inflammation. Our monocyte activation assay can help you detect any potential drug impurities as well as understanding the safety profile of your drug.
Study monocyte activation to:
Better understand the safety profile of your drug.
Investigate proinflammatory cytokine and chemokine production.
Investigate complement activation.
Detect impurities of your drug substance including impurities between different batches.
Obtain sensitive results based on the human immune reaction.
About the assay
Samples are created in Immuneed’s in-vitro model of circulating human blood.
Phenotypical analysis of monocyte activation is carried out with Flow Cytometry / FACS.
Any cell type of the blood can be included in the same run which makes the assay highly cost efficient. For additional cell types please see immune profiling.
The assay also enables you to understand downstream processes related to drug binding including cell activation, cargo uptake, internalization, shedding, trogocytosis and phagocytosis. Head to cell binding and activation to read more.
We're happy to answer questions and get you acquainted with Immuneed.