ID.Flow® An Ex Vivo Test System Mimicking Human Blood Circulation

ID.Flow® is a physiologically relevant ex vivo sample-generating test system that provides multiple readouts to understand drug candidates better and de-risk first-in-human studies.

Features & Benefits

  • ID.Flow is in line with the 3Rs and New Approach Methodologies requirements.
  • High-quality data from a physiologically relevant environment is produced.
  • Multiple readouts are evaluated in the same study and donors, including activation of sensitive cells and cascade systems such as granulocytes, monocytes, platelets, and complement factors.
  • Fresh, minimally manipulated blood means the complexity is kept intact during the assessment.

Here's how it works

1. DONATED BLOOD

The blood is donated on-site. Using fresh, minimally manipulated blood enables cascade systems, immune cells, and serum proteins to remain intact during analysis.

2. IMMEDIATE ANALYSIS

Blood is immediately transferred to ID.Flow and controls and test substances are added to separate units of blood.

3. BLOOD CIRCULATION

The blood circulates at 37°C, enabling interactions between blood cells, components, and test substances in a physiologically relevant manner.

4. SAMPLE GENERATION

ID.Flow generates samples that are used for analyzing multiple immunotoxicity and efficacy readouts.

5.MULTIPLE READOUTS

Cytokines Complement activation White blood cells counts & activation Platelet counts & activation Blood parameters

6.DATA & REPORTING

Our experienced scientists interpret the data and deliver a scientific report tailored to the specific purpose (IND/CTA, internal use etc.)

ID.Flow®

A Powerful Tool in the Nonclinical Toolbox

ID.Flow is an important tool to add to your nonclinical drug development toolbox.

  • Immuneed has supported more than 140 preclinical drug development projects and ID.Flow® data has been submitted both to the FDA and the EMA.
  • By providing physiologically relevant data and analyzing multiple readouts in blood donated at the same time from the same donors, we can help you bridge the gap to the clinic phase.